Genetic inhibition of the atypical kinase Wee1 selectively drives apoptosis of p53 inactive tumor cells

Por Pappano, William N, Zhang, Qian, Tucker, Lora A, Tse, Chris, Wang, Jieyi
Publicado no BMC Cancer (2014)

Use of Bmp1/Tll1 Doubly Homozygous Null Mice and Proteomics To Identify and Validate In Vivo Substrates of Bone Morphogenetic Protein 1/Tolloid-Like Metalloproteinases

Por Pappano, William N., Steiglitz, Barry M., Scott, Ian C., Keene, Douglas R., Greenspan, Daniel S.
Publicado em 2003

Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response

Por Williams, Elizabeth H., Pappano, William N., Saunders, Adam M., Kim, Min-Sung, Leahy, Daniel J., Beachy, Philip A.
Publicado em 2010

Procollagen C Proteinase Enhancer 1 Genes Are Important Determinants of the Mechanical Properties and Geometry of Bone and the Ultrastructure of Connective Tissues

Por Steiglitz, Barry M., Kreider, Jaclynn M., Frankenburg, Elizabeth P., Pappano, William N., Hoffman, Guy G., Meganck, Jeffrey A., Liang, Xiaowen, Höök, Magnus, Birk, David E., Goldstein, Steven A., Greenspan, Daniel S.
Publicado em 2006

Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases

Por Wolfman, Neil M., McPherron, Alexandra C., Pappano, William N., Davies, Monique V., Song, Kening, Tomkinson, Kathleen N., Wright, Jill F., Zhao, Liz, Sebald, Suzanne M., Greenspan, Daniel S., Lee, Se-Jin
Publicado em 2003

Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a

Por Sweis, Ramzi F., Pliushchev, Marina, Brown, Peter J., Guo, Jun, Li, Fengling, Maag, David, Petros, Andrew M., Soni, Nirupama B., Tse, Chris, Vedadi, Masoud, Michaelides, Michael R., Chiang, Gary G., Pappano, William N.
Publicado em 2014

Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8

Por Judge, Russell A., Zhu, Haizhong, Upadhyay, Anup K., Bodelle, Pierre M., Hutchins, Charles W., Torrent, Maricel, Marin, Violeta L., Yu, Wenyu, Vedadi, Masoud, Li, Fengling, Brown, Peter J., Pappano, William N., Sun, Chaohong, Petros, Andrew M.
Publicado no ACS Med Chem Lett (2016)

Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2

Por Sweis, Ramzi F., Wang, Zhi, Algire, Mikkel, Arrowsmith, Cheryl H., Brown, Peter J., Chiang, Gary G., Guo, Jun, Jakob, Clarissa G., Kennedy, Steven, Li, Fengling, Maag, David, Shaw, Bailin, Soni, Nirupama B., Vedadi, Masoud, Pappano, William N.
Publicado no ACS Med Chem Lett (2015)

The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia

Por Pappano, William N., Guo, Jun, He, Yupeng, Ferguson, Debra, Jagadeeswaran, Sujatha, Osterling, Donald J., Gao, Wenqing, Spence, Julie K., Pliushchev, Marina, Sweis, Ramzi F., Buchanan, Fritz G., Michaelides, Michael R., Shoemaker, Alexander R., Tse, Chris, Chiang, Gary G.
Publicado no PLoS One (2015)

Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification

Por Wang, Jieyi, Goetsch, Liliane, Tucker, Lora, Zhang, Qian, Gonzalez, Alexandra, Vaidya, Kedar S., Oleksijew, Anatol, Boghaert, Erwin, Song, Minghao, Sokolova, Irina, Pestova, Ekaterina, Anderson, Mark, Pappano, William N., Ansell, Peter, Bhathena, Anahita, Naumovski, Louie, Corvaia, Nathalie, Reilly, Edward B.
Publicado no BMC Cancer (2016)

Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605

Por Buchanan Fritz G, Donawho Cherrie, Sheppard George S, Johnson Eric F, Soni Niru B, Grudzien Meagan M, Zhang Qian, Hubbard Robert D, Wang Yi-Chun, Meulbroek Jonathan A, Jung Paul M, Pappano William N, Davidsen Steven K, Bell Randy L, Wang Jieyi
Publicado em 2009-09-01

Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605

Por Pappano, William N, Jung, Paul M, Meulbroek, Jonathan A, Wang, Yi-Chun, Hubbard, Robert D, Zhang, Qian, Grudzien, Meagan M, Soni, Niru B, Johnson, Eric F, Sheppard, George S, Donawho, Cherrie, Buchanan, Fritz G, Davidsen, Steven K, Bell, Randy L, Wang, Jieyi
Publicado em 2009