Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2

[Image: see text] A lack of useful small molecule tools has precluded thorough interrogation of the biological function of SMYD2, a lysine methyltransferase with known tumor-suppressor substrates. Systematic exploration of the structure–activity relationships of a previously known benzoxazinone comp...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Sweis, Ramzi F., Wang, Zhi, Algire, Mikkel, Arrowsmith, Cheryl H., Brown, Peter J., Chiang, Gary G., Guo, Jun, Jakob, Clarissa G., Kennedy, Steven, Li, Fengling, Maag, David, Shaw, Bailin, Soni, Nirupama B., Vedadi, Masoud, Pappano, William N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468393/
https://ncbi.nlm.nih.gov/pubmed/26101576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00124
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