Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8

[Image: see text] SETD8 is a histone H4–K20 methyltransferase that plays an essential role in the maintenance of genomic integrity during mitosis and in DNA damage repair, making it an intriguing target for cancer research. While some small molecule inhibitors for SETD8 have been reported, the struc...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Judge, Russell A., Zhu, Haizhong, Upadhyay, Anup K., Bodelle, Pierre M., Hutchins, Charles W., Torrent, Maricel, Marin, Violeta L., Yu, Wenyu, Vedadi, Masoud, Li, Fengling, Brown, Peter J., Pappano, William N., Sun, Chaohong, Petros, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150682/
https://ncbi.nlm.nih.gov/pubmed/27994746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00303
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