Metallo-β-lactamase structure and function

by Palzkill, Timothy
Published 2012

Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC β-lactamases

by Palzkill, Timothy
Published in Front Mol Biosci (2018)

A natural polymorphism in β-lactamase is a global suppressor

by Huang, Wanzhi, Palzkill, Timothy
Published 1997

Amino Acid Sequence Requirements at Residues 69 and 238 for the SME-1 β-Lactamase To Confer Resistance to β-Lactam Antibiotics

by Majiduddin, Fahd K., Palzkill, Timothy
Published 2003

Amino Acid Residues That Contribute to Substrate Specificity of Class A β-Lactamase SME-1

by Majiduddin, Fahd K., Palzkill, Timothy
Published 2005

An analysis of why highly similar enzymes evolve differently.

by Majiduddin, Fahd K, Palzkill, Timothy
Published 2003

Identification of residues critical for metallo-β-lactamase function by codon randomization and selection

by Materon, Isabel C., Palzkill, Timothy
Published 2001

Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A β-lactamases

by Adamski, Carolyn J., Palzkill, Timothy
Published in BMC Biochem (2017)

BLIP-II employs differential hotspot residues to bind structurally similar Staphylococcus aureus PBP2a and class A β-lactamases

by Adamski, Carolyn J., Palzkill, Timothy
Published in Biochemistry (2017)

Display of Functional β-Lactamase Inhibitory Protein on the Surface of M13 Bacteriophage

by Huang, Wanzhi, Petrosino, Joseph, Palzkill, Timothy
Published 1998

Binding Properties of a Peptide Derived from β-Lactamase Inhibitory Protein

by Rudgers, Gary W., Huang, Wanzhi, Palzkill, Timothy
Published 2001

Structural Insight into the Kinetics and ΔCp of Interactions between TEM-1 β-Lactamase and β-Lactamase Inhibitory Protein (BLIP)

by Wang, Jihong, Palzkill, Timothy, Chow, Dar-Chone
Published 2009

Neutral β-Lactams Inactivate High Molecular Mass Penicillin-Binding Proteins of Class B1, Including PBP2a of MRSA

by Dave, Kinjal, Palzkill, Timothy, Pratt, R. F.
Published 2013

Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability

by Mehta, Shrenik C., Rice, Kacie, Palzkill, Timothy
Published in PLoS Pathog (2015)

A Fitness Cost Associated With the Antibiotic Resistance Enzyme SME-1 β-Lactamase

by Marciano, David C., Karkouti, Omid Y., Palzkill, Timothy
Published 2007

Analysis of the plasticity of location of the Arg244 positive charge within the active site of the TEM-1 β-lactamase

by Marciano, David C, Brown, Nicholas G, Palzkill, Timothy
Published 2009

BLIP-II Is a Highly Potent Inhibitor of Klebsiella pneumoniae Carbapenemase (KPC-2)

by Brown, Nicholas G., Chow, Dar-Chone, Palzkill, Timothy
Published 2013

How Structural and Physicochemical Determinants Shape Sequence Constraints in a Functional Enzyme

by Abriata, Luciano A., Palzkill, Timothy, Dal Peraro, Matteo
Published in PLoS One (2015)

Characterization of the Global Stabilizing Substitution A77V and Its Role in the Evolution of CTX-M β-Lactamases

by Patel, Meha P., Fryszczyn, Bartlomiej G., Palzkill, Timothy
Published in Antimicrob Agents Chemother (2015)

Mapping Protein-Protein Interaction Interface Peptides with Jun-Fos Assisted Phage Display and Deep Sequencing

by Huang, Wanzhi, Soeung, Victoria, Boragine, David, Palzkill, Timothy
Published in ACS Synth Biol (2020)