DIPG-43. PROLONGED CONVECTION-ENHANCED DELIVERY IN THE PONS WITH SN-38 LOADED NANOPARTICLES AND IRINOTECAN

por Sewing, A Charlotte, Olaciregui, Nagore G, Monterrubio, Carles, Kaspers, Gertjan, Mora, Jaume, Hulleman, Esther, Carcaboso, Angel M
Publicado en Neuro Oncol (2017)

HG-96 FUNCTIONAL INTEGRITY OF THE BLOOD-BRAIN BARRIER IN H3.3K27M DIPG XENOGRAFTS

por Olaciregui, Nagore G., Madrid, Andres Morales La, Monterrubio, Carles, Pascual-Pasto, Guillem, Manzanares, Alejandro, Cruz, Ofelia, Mora, Jaume, Carcaboso, Angel M.
Publicado en Neuro Oncol (2016)

DIPG-29. PRECLINICAL EFFICACY OF COMBINED ACVR1 AND PI3K/mTOR INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

por Carvalho, Diana, Olaciregui, Nagore Gene, Ruddle, Ruth, Donovan, Adam, Pal, Akos, Raynaud, Florence, Richardson, Peter J, Carcaboso, Angel Montero, Jones, Chris
Publicado en Neuro Oncol (2018)

Characterization of the Blood–Brain Barrier Integrity and the Brain Transport of SN-38 in an Orthotopic Xenograft Rat Model of Diffuse Intrinsic Pontine Glioma

por Chaves, Catarina, Declèves, Xavier, Taghi, Meryam, Menet, Marie-Claude, Lacombe, Joelle, Varlet, Pascale, Olaciregui, Nagore G., Carcaboso, Angel M., Cisternino, Salvatore
Publicado en Pharmaceutics (2020)

Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models

por Hennika, Tammy, Hu, Guo, Olaciregui, Nagore G., Barton, Kelly L., Ehteda, Anahid, Chitranjan, Arjanna, Chang, Cecilia, Gifford, Andrew J., Tsoli, Maria, Ziegler, David S., Carcaboso, Angel M., Becher, Oren J.
Publicado en PLoS One (2017)

Efficacy of systemic temozolomide‐activated phage‐targeted gene therapy in human glioblastoma

por Przystal, Justyna Magdalena, Waramit, Sajee, Pranjol, Md Zahidul Islam, Yan, Wenqing, Chu, Grace, Chongchai, Aitthiphon, Samarth, Gargi, Olaciregui, Nagore Gene, Tabatabai, Ghazaleh, Carcaboso, Angel Montero, Aboagye, Eric Ofori, Suwan, Keittisak, Hajitou, Amin
Publicado en EMBO Mol Med (2019)

DIPG-49. STAT3 AS A THERAPEUTIC TARGET IN DIPG

por Olaciregui, Nagore G, Carvalho, Diana, Mackay, Alan, Pascual-Pasto, Guillem, Clarke, Matthew, Molinari, Valeria, Izquierdo, Elisa, Goncalves, Jordan, Courbebaisse, Yann, La Madrid, Andres Morales, Suñol, Mariona, Cruz, Ofelia, Mora, Jaume, Jones, Chris, Carcaboso, Angel M
Publicado en Neuro Oncol (2018)

Targeted drug distribution in tumor extracellular fluid of GD2-expressing neuroblastoma patient-derived xenografts using SN-38-loaded nanoparticles conjugated to the monoclonal ant...

por Monterrubio, Carles, Paco, Sonia, Olaciregui, Nagore G., Pascual-Pasto, Guillem, Vila-Ubach, Monica, Cuadrado-Vilanova, Maria, Ferrandiz, M. Mar, Castillo-Ecija, Helena, Glisoni, Romina, Kuplennik, Nataliya, Jungbluth, Achim, de Torres, Carmen, Lavarino, Cinzia, Cheung, Nai-Kong V., Mora, Jaume, Sosnik, Alejandro, Carcaboso, Angel M.
Publicado en J Control Release (2017)

HG-67 PRECLINICAL EFFICACY OF ALK2 INHIBITORS IN ACVR1 MUTANT DIPG

por Carvalho, Diana, Taylor, Kathryn, Olaciregui, Nagore G., Valenti, Melanie, Ruddle, Ruth, Henley, Alan, Hayes, Angela, Brandon, Alexis De Haven, Hallsworth, Albert, Mackay, Alan, Molinari, Valeria, Vinci, Maria, Popov, Sergey, Boudhar, Aicha, Brennan, Paul, Moore, Andrew, Hudson, Liam, Hoelder, Swen, Bullock, Alex, Raynaud, Florence, Eccles, Sue, Carcaboso, Angel M., Jones, Chris
Publicado en Neuro Oncol (2016)

WNT-activated embryonal tumors of the pineal region: ectopic medulloblastomas or a novel pineoblastoma subgroup?

por Liu, Anthony P.Y., Priesterbach-Ackley, Loudy P., Orr, Brent A., Li, Bryan K., Gudenas, Brian, Reddingius, Roel E., Suñol, Mariona, Lavarino, Cinzia E., Olaciregui, Nagore G., Lopez, Vicente Santa-Maria, Fisher, Michael J., Hazrati, Lili-Naz, Bouffet, Eric, Huang, Annie, Robinson, Giles W., Wesseling, Pieter, Northcott, Paul A., Gajjar, Amar
Publicado en Acta Neuropathol (2020)

EXTH-46. ARTIFICIAL INTELLIGENCE-BASED IDENTIFICATION OF COMBINED VANDETANIB AND EVEROLIMUS IN THE TREATMENT OF ACVR1-MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA

por Carvalho, Diana, Richardson, Peter, Olaciregui, Nagore Gene, Stankunaite, Reda, Lavarino, Cinzia Emilia, Molinari, Valeria, Corley, Elizabeth, Ruddle, Ruth, Donovan, Adam, Pal, Akos, Raynaud, Florence I, Overington, John P, Phelan, Anne, Sheppard, Dave, Mackinnon, Andrew, Hubank, Michael, Cruz, Ofelia, Madrid, Andres Morales La, Mueller, Sabine, Carcaboso, Angel Montero, Carceller, Fernando, Jones, Chris
Publicado en Neuro Oncol (2020)

ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma

por Carvalho, Diana, Taylor, Kathryn R., Olaciregui, Nagore Gene, Molinari, Valeria, Clarke, Matthew, Mackay, Alan, Ruddle, Ruth, Henley, Alan, Valenti, Melanie, Hayes, Angela, Brandon, Alexis De Haven, Eccles, Suzanne A., Raynaud, Florence, Boudhar, Aicha, Monje, Michelle, Popov, Sergey, Moore, Andrew S., Mora, Jaume, Cruz, Ofelia, Vinci, Mara, Brennan, Paul E., Bullock, Alex N., Carcaboso, Angel Montero, Jones, Chris
Publicado en Commun Biol (2019)

PDTM-31. DRUG SCREENING LINKED TO MOLECULAR PROFILING IDENTIFIES NOVEL DEPENDENCIES IN PATIENT-DERIVED PRIMARY CULTURES OF PAEDIATRIC HIGH GRADE GLIOMA AND DIPG

por Mackay, Alan, Carvalho, Diana, Molinari, Valeria, Pemberton, Helen, Temelso, Sara, Burford, Anna, Clarke, Matthew, Fofana, Mariama, Boult, Jessica, Izquierdo, Elisa, Taylor, Katy, Bjerke, Lynn, Fazal Salom, Janat, Kessler, Ketty, Rogers, Rebecca, Marshall, Lynley, Carceller, Fernando, Pears, Jane, Moore, Andrew, Miele, Evelina, Carai, Andrea, Mastronuzzi, Angela, Robinson, Simon, Lord, Chris, Olaciregui, Nagore, Mora, Jaume, Montero Carcaboso, Angel, Hargrave, Darren, Vinci, Maria, Jones, Chris
Publicado en Neuro Oncol (2018)

Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma

por Carvalho, Diana M., Richardson, Peter J., Olaciregui, Nagore, Stankunaite, Reda, Lavarino, Cinzia, Molinari, Valeria, Corley, Elizabeth A., Smith, Daniel P., Ruddle, Ruth, Donovan, Adam, Pal, Akos, Raynaud, Florence I., Temelso, Sara, Mackay, Alan, Overington, John P., Phelan, Anne, Sheppard, David, Mackinnon, Andrew, Zebian, Bassel, Al-Sarraj, Safa, Merve, Ashirwad, Pryce, Jeremy, Grill, Jacques, Hubank, Michael, Cruz, Ofelia, Morales La Madrid, Andres, Mueller, Sabine, Carcaboso, Angel M., Carceller, Fernando, Jones, Chris
Publicado en Cancer Discov (2022)

Prognostic value of patient‐derived xenograft engraftment in pediatric sarcomas

por Castillo‐Ecija, Helena, Pascual‐Pasto, Guillem, Perez‐Jaume, Sara, Resa‐Pares, Claudia, Vila‐Ubach, Monica, Monterrubio, Carles, Jimenez‐Cabaco, Ana, Baulenas‐Farres, Merce, Muñoz‐Aznar, Oscar, Salvador, Noelia, Cuadrado‐Vilanova, Maria, Olaciregui, Nagore G, Balaguer‐Lluna, Leire, Burgueño, Victor, Vicario, Francisco J, Manzanares, Alejandro, Castañeda, Alicia, Santa‐Maria, Vicente, Cruz, Ofelia, Celis, Veronica, Morales La Madrid, Andres, Garraus, Moira, Gorostegui, Maite, Vancells, Margarita, Carrasco, Rosalia, Krauel, Lucas, Torner, Ferran, Suñol, Mariona, Lavarino, Cinzia, Mora, Jaume, Carcaboso, Angel M
Publicado en J Pathol Clin Res (2021)

HG-99 A PATIENT-DERIVED PAEDIATRIC HIGH GRADE GLIOMA AND DIPG CELL CULTURE PANEL RECAPITULATING THE GENOTYPIC AND PHENOTYPIC DIVERSITY OF THE DISEASE

por Vinci, Mara, Molinari, Valeria, Taylor, Kathryn, Carvalho, Diana, Burford, Anna, Mackay, Alan, Popov, Sergey, Fofama, Mariama, Fazal-Salom, Janat, Bjerke, Lynn, Boult, Jessica K.R., Pemberton, Helen, Lord, Christopher J., Howell, Louise, Pears, Jane, Mastronuzzi, Angela, Carai, Andrea, Marshall, Lynley V., Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C., Bridges, Leslie R., Martin, Andrew J., Al-Sarraj, Safa, Chandler, Christopher, Robinson, Simon P., Olaciregui, Nagore G., Sunol, Mariona, Mora, Jaume, de Torres, Carmen, Cruz, Ofelia, Monje, Michelle, Moore, Andrew S., Carcaboso, Angel M., Jones, Chris
Publicado en Neuro Oncol (2016)