Targeted drug distribution in tumor extracellular fluid of GD2-expressing neuroblastoma patient-derived xenografts using SN-38-loaded nanoparticles conjugated to the monoclonal antibody 3F8

Neuroblastoma is a pediatric solid tumor with high expression of the tumor associated antigen disialoganglioside GD2. Despite initial response to induction therapy, nearly 50% of high-risk neuroblastomas recur because of chemoresistance. Here we encapsulated the topoisomerase-I inhibitor SN-38 in po...

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Publicat a:J Control Release
Autors principals: Monterrubio, Carles, Paco, Sonia, Olaciregui, Nagore G., Pascual-Pasto, Guillem, Vila-Ubach, Monica, Cuadrado-Vilanova, Maria, Ferrandiz, M. Mar, Castillo-Ecija, Helena, Glisoni, Romina, Kuplennik, Nataliya, Jungbluth, Achim, de Torres, Carmen, Lavarino, Cinzia, Cheung, Nai-Kong V., Mora, Jaume, Sosnik, Alejandro, Carcaboso, Angel M.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564453/
https://ncbi.nlm.nih.gov/pubmed/28412222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2017.04.016
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