Irreversibility of cellular senescence: dual roles of p16(INK4a)/Rb-pathway in cell cycle control

Por Takahashi, Akiko, Ohtani, Naoko, Hara, Eiji
Publicado em 2007

Real-time in vivo imaging of p16(Ink4a )gene expression: a new approach to study senescence stress signaling in living animals

Por Ohtani, Naoko, Yamakoshi, Kimi, Takahashi, Akiko, Hara, Eiji
Publicado em 2010

Impact of senescence‐associated secretory phenotype and its potential as a therapeutic target for senescence‐associated diseases

Por Watanabe, Sugiko, Kawamoto, Shimpei, Ohtani, Naoko, Hara, Eiji
Publicado no Cancer Sci (2017)

Adverse effects of maternal exposure to bisphenol F on the anxiety- and depression-like behavior of offspring

Por OHTANI, Naoko, IWANO, Hidetomo, SUDA, Koshi, TSUJI, Erika, TANEMURA, Kentaro, INOUE, Hiroki, YOKOTA, Hiroshi
Publicado no J Vet Med Sci (2016)

Late pregnancy is vulnerable period for exposure to BPA

Por OHTANI, Naoko, SUDA, Koshi, TSUJI, Erika, TANEMURA, Kentaro, YOKOTA, Hiroshi, INOUE, Hiroki, IWANO, Hidetomo
Publicado no J Vet Med Sci (2018)

Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53

Por Maehara, Kayoko, Yamakoshi, Kimi, Ohtani, Naoko, Kubo, Yoshiaki, Takahashi, Akiko, Arase, Seiji, Jones, Nic, Hara, Eiji
Publicado em 2005

Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development

Por YABUSAKI, Risa, IWANO, Hidetomo, TSUSHIMA, Sumito, KOIKE, Nanako, OHTANI, Naoko, TANEMURA, Kentaro, INOUE, Hiroki, YOKOTA, Hiroshi
Publicado no J Vet Med Sci (2015)

Epstein-Barr virus LMP1 blocks p16(INK4a)–RB pathway by promoting nuclear export of E2F4/5

Por Ohtani, Naoko, Brennan, Paul, Gaubatz, Stefan, Sanij, Elaine, Hertzog, Paul, Wolvetang, Ernst, Ghysdael, Jacques, Rowe, Martin, Hara, Eiji
Publicado em 2003

Dysregulation of the Bmi-1/p16(Ink4a) pathway provokes an aging-associated decline of submandibular gland function

Por Yamakoshi, Kimi, Katano, Satoshi, Iida, Mayu, Kimura, Hiromi, Okuma, Atsushi, Ikemoto-Uezumi, Madoka, Ohtani, Naoko, Hara, Eiji, Maruyama, Mitsuo
Publicado no Aging Cell (2015)

Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)

Por Sugimoto, Masataka, Nakamura, Takeshi, Ohtani, Naoko, Hampson, Lynne, Hampson, Ian N., Shimamoto, Akira, Furuichi, Yasuhiro, Okumura, Ko, Niwa, Shinichiro, Taya, Yoichi, Hara, Eiji
Publicado em 1999

Functional association of cellular microtubules with viral capsid assembly supports efficient hepatitis B virus replication

Por Iwamoto, Masashi, Cai, Dawei, Sugiyama, Masaya, Suzuki, Ryosuke, Aizaki, Hideki, Ryo, Akihide, Ohtani, Naoko, Tanaka, Yasuhito, Mizokami, Masashi, Wakita, Takaji, Guo, Haitao, Watashi, Koichi
Publicado no Sci Rep (2017)

Rituximab Treatment for PR3-ANCA-Positive Membranoproliferative Glomerulonephritis Associated with Adult-Onset Periodic Fever Syndrome

Por Hamano, Yoshitomo, Yoshizawa, Hiromichi, Sugase, Taro, Miki, Takuya, Ohtani, Naoko, Hanawa, Shiho, Takeshima, Eri, Morishita, Yoshiyuki, Saito, Osamu, Takemoto, Fumi, Muto, Shigeaki, Yumura, Wako, Kusano, Eiji
Publicado em 2012

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Por Takahashi, Akiko, Loo, Tze Mun, Okada, Ryo, Kamachi, Fumitaka, Watanabe, Yoshihiro, Wakita, Masahiro, Watanabe, Sugiko, Kawamoto, Shimpei, Miyata, Kenichi, Barber, Glen N., Ohtani, Naoko, Hara, Eiji
Publicado no Nat Commun (2018)

Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice

Por Sato, Seidai, Kawamata, Yuka, Takahashi, Akiko, Imai, Yoshinori, Hanyu, Aki, Okuma, Atsushi, Takasugi, Masaki, Yamakoshi, Kimi, Sorimachi, Hiroyuki, Kanda, Hiroaki, Ishikawa, Yuichi, Sone, Saburo, Nishioka, Yasuhiko, Ohtani, Naoko, Hara, Eiji
Publicado no Nat Commun (2015)

Real-time in vivo imaging of p16(Ink4a) reveals cross talk with p53

Por Yamakoshi, Kimi, Takahashi, Akiko, Hirota, Fumiko, Nakayama, Rika, Ishimaru, Naozumi, Kubo, Yoshiaki, Mann, David J., Ohmura, Masako, Hirao, Atsushi, Saya, Hideyuki, Arase, Seiji, Hayashi, Yoshio, Nakao, Kazuki, Matsumoto, Mitsuru, Ohtani, Naoko, Hara, Eiji
Publicado em 2009

Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals

Por Ohtani, Naoko, Imamura, Yuko, Yamakoshi, Kimi, Hirota, Fumiko, Nakayama, Rika, Kubo, Yoshiaki, Ishimaru, Naozumi, Takahashi, Akiko, Hirao, Atsushi, Shimizu, Takatsune, Mann, David J., Saya, Hideyuki, Hayashi, Yoshio, Arase, Seiji, Matsumoto, Mitsuru, Kazuki, Nakao, Hara, Eiji
Publicado em 2007

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Por Demaria, Marco, Ohtani, Naoko, Youssef, Sameh A., Rodier, Francis, Toussaint, Wendy, Mitchell, James R., Laberge, Remi-Martin, Vijg, Jan, Van Steeg, Harry, Dollé, Martijn E.T., Hoeijmakers, Jan H.J., de Bruin, Alain, Hara, Eiji, Campisi, Judith
Publicado no Dev Cell (2014)

A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide

Por Kaneko, Manabu, Watashi, Koichi, Kamisuki, Shinji, Matsunaga, Hiroki, Iwamoto, Masashi, Kawai, Fumihiro, Ohashi, Hirofumi, Tsukuda, Senko, Shimura, Satomi, Suzuki, Ryosuke, Aizaki, Hideki, Sugiyama, Masaya, Park, Sam-Yong, Ito, Takayoshi, Ohtani, Naoko, Sugawara, Fumio, Tanaka, Yasuhito, Mizokami, Masashi, Sureau, Camille, Wakita, Takaji
Publicado no J Virol (2015)

Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide

Por Kaneko, Manabu, Futamura, Yushi, Tsukuda, Senko, Kondoh, Yasumitsu, Sekine, Tomomi, Hirano, Hiroyuki, Fukano, Kento, Ohashi, Hirofumi, Saso, Wakana, Morishita, Ryo, Matsunaga, Satoko, Kawai, Fumihiro, Ryo, Akihide, Park, Sam-Yong, Suzuki, Ryosuke, Aizaki, Hideki, Ohtani, Naoko, Sureau, Camille, Wakita, Takaji, Osada, Hiroyuki, Watashi, Koichi
Publicado no Sci Rep (2018)