Dysregulation of the Bmi-1/p16(Ink4a) pathway provokes an aging-associated decline of submandibular gland function

Bmi-1 prevents stem cell aging, at least partly, by blocking expression of the cyclin-dependent kinase inhibitor p16(Ink4a). Therefore, dysregulation of the Bmi-1/p16(Ink4a) pathway is considered key to the loss of tissue homeostasis and development of associated degenerative diseases during aging....

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Yamakoshi, Kimi, Katano, Satoshi, Iida, Mayu, Kimura, Hiromi, Okuma, Atsushi, Ikemoto-Uezumi, Madoka, Ohtani, Naoko, Hara, Eiji, Maruyama, Mitsuo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4531075/
https://ncbi.nlm.nih.gov/pubmed/25832744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12337
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