Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice

The p16(INK4a) tumour suppressor has an established role in the implementation of cellular senescence in stem/progenitor cells, which is thought to contribute to organismal ageing. However, since p16(INK4a) knockout mice die prematurely from cancer, whether p16(INK4a) reduces longevity remains uncle...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Sato, Seidai, Kawamata, Yuka, Takahashi, Akiko, Imai, Yoshinori, Hanyu, Aki, Okuma, Atsushi, Takasugi, Masaki, Yamakoshi, Kimi, Sorimachi, Hiroyuki, Kanda, Hiroaki, Ishikawa, Yuichi, Sone, Saburo, Nishioka, Yasuhiko, Ohtani, Naoko, Hara, Eiji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421814/
https://ncbi.nlm.nih.gov/pubmed/25923845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8035
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados