Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice

The p16(INK4a) tumour suppressor has an established role in the implementation of cellular senescence in stem/progenitor cells, which is thought to contribute to organismal ageing. However, since p16(INK4a) knockout mice die prematurely from cancer, whether p16(INK4a) reduces longevity remains uncle...

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Publicado en:Nat Commun
Autores principales: Sato, Seidai, Kawamata, Yuka, Takahashi, Akiko, Imai, Yoshinori, Hanyu, Aki, Okuma, Atsushi, Takasugi, Masaki, Yamakoshi, Kimi, Sorimachi, Hiroyuki, Kanda, Hiroaki, Ishikawa, Yuichi, Sone, Saburo, Nishioka, Yasuhiko, Ohtani, Naoko, Hara, Eiji
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Pub. Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421814/
https://ncbi.nlm.nih.gov/pubmed/25923845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8035
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