p16(Ink4a) and p21(Cip1/Waf1) promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis

p16(Ink4a) and p21(Cip1/Waf1) act as tumour suppressors through induction of cellular senescence. However, senescence-independent roles of these CDK inhibitors are not well understood. Here, we report an unexpected function of p16(Ink4) and p21(Cip1/Waf1), namely, tumour promotion through chemotaxis...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Okuma, Atsushi, Hanyu, Aki, Watanabe, Sugiko, Hara, Eiji
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727112/
https://ncbi.nlm.nih.gov/pubmed/29234059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02281-x
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