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p16(Ink4a) and p21(Cip1/Waf1) promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
p16(Ink4a) and p21(Cip1/Waf1) act as tumour suppressors through induction of cellular senescence. However, senescence-independent roles of these CDK inhibitors are not well understood. Here, we report an unexpected function of p16(Ink4) and p21(Cip1/Waf1), namely, tumour promotion through chemotaxis...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5727112/ https://ncbi.nlm.nih.gov/pubmed/29234059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02281-x |
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