Cathepsin L Inhibition Prevents Murine Autoimmune Diabetes via Suppression of CD8(+) T Cell Activity

Por Yamada, Akiko, Ishimaru, Naozumi, Arakaki, Rieko, Katunuma, Nobuhiko, Hayashi, Yoshio
Publicado em 2010

An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

Por Pillaiyar, Thanigaimalai, Manickam, Manoj, Namasivayam, Vigneshwaran, Hayashi, Yoshio, Jung, Sang-Hun
Publicado no J Med Chem (2016)

Analysis of in Vivo Role of α-Fodrin Autoantigen in Primary Sjögren’s Syndrome

Por Miyazaki, Katsushi, Takeda, Noriaki, Ishimaru, Naozumi, Omotehara, Fumie, Arakaki, Rieko, Hayashi, Yoshio
Publicado em 2005

Estrogen Deficiency Accelerates Autoimmune Exocrinopathy in Murine Sjögren’s Syndrome through Fas-Mediated Apoptosis

Por Ishimaru, Naozumi, Saegusa, Kaoru, Yanagi, Kumiko, Haneji, Norio, Saito, Ichiro, Hayashi, Yoshio
Publicado em 1999

Development of Autoimmune Exocrinopathy Resembling Sjögren’s Syndrome in Estrogen-Deficient Mice of Healthy Background

Por Ishimaru, Naozumi, Arakaki, Rieko, Watanabe, Megumi, Kobayashi, Masaru, Miyazaki, Katsushi, Hayashi, Yoshio
Publicado em 2003

Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome–like autoimmune exocrinopathy

Por Ishimaru, Naozumi, Arakaki, Rieko, Yoshida, Satoko, Yamada, Akiko, Noji, Sumihare, Hayashi, Yoshio
Publicado em 2008

Role of Plasmacytoid Dendritic Cells for Aberrant Class II Expression in Exocrine Glands from Estrogen-Deficient Mice of Healthy Background

Por Arakaki, Rieko, Nagaoka, Ai, Ishimaru, Naozumi, Yamada, Akiko, Yoshida, Satoko, Hayashi, Yoshio
Publicado em 2009

Slower immune system aging in women versus men in the Japanese population

Por Hirokawa, Katsuiku, Utsuyama, Masanori, Hayashi, Yoshio, Kitagawa, Masanobu, Makinodan, Takashi, Fulop, Tamas
Publicado em 2013

KPU-300, a Novel Benzophenone–Diketopiperazine–Type Anti-Microtubule Agent with a 2-Pyridyl Structure, Is a Potent Radiosensitizer That Synchronizes the Cell Cycle in Early M Phase...

Por Okuyama, Kohei, Kaida, Atsushi, Hayashi, Yoshiki, Hayashi, Yoshio, Harada, Kiyoshi, Miura, Masahiko
Publicado no PLoS One (2015)

Structural Basis for the Effective Myostatin Inhibition of the Mouse Myostatin Prodomain-Derived Minimum Peptide

Por Asari, Tomo, Takayama, Kentaro, Nakamura, Akari, Shimada, Takahiro, Taguchi, Akihiro, Hayashi, Yoshio
Publicado no ACS Med Chem Lett (2016)

Novel Role for RbAp48 in Tissue-Specific, Estrogen Deficiency-Dependent Apoptosis in the Exocrine Glands

Por Ishimaru, Naozumi, Arakaki, Rieko, Omotehara, Fumie, Yamada, Koichi, Mishima, Kenji, Saito, Ichiro, Hayashi, Yoshio
Publicado em 2006

In Situ Patrolling of Regulatory T Cells Is Essential for Protecting Autoimmune Exocrinopathy

Por Ishimaru, Naozumi, Nitta, Takeshi, Arakaki, Rieko, Yamada, Akiko, Lipp, Martin, Takahama, Yousuke, Hayashi, Yoshio
Publicado em 2010

Induction of Rapid T Cell Death and Phagocytic Activity by Fas-Deficient lpr Macrophages

Por Oura, Ritsuko, Arakaki, Rieko, Yamada, Akiko, Kudo, Yasusei, Tanaka, Eiji, Hayashi, Yoshio, Ishimaru, Naozumi
Publicado em 2013

New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors

Por Regnier, Thomas, Sarma, Diganta, Hidaka, Koushi, Bacha, Usman, Freire, Ernesto, Hayashi, Yoshio, Kiso, Yoshiaki
Publicado no Bioorg Med Chem Lett (2009)

A Novel DC Therapy with Manipulation of MKK6 Gene on Nickel Allergy in Mice

Por Watanabe, Megumi, Ishimaru, Naozumi, Ashrin, Meinar Nur, Arakaki, Rieko, Yamada, Akiko, Ichikawa, Tetsuo, Hayashi, Yoshio
Publicado em 2011

Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity

Por Saegusa, Kaoru, Ishimaru, Naozumi, Yanagi, Kumiko, Arakaki, Rieko, Ogawa, Kouichi, Saito, Ichiro, Katunuma, Nobuhiko, Hayashi, Yoshio
Publicado em 2002

Severe Destructive Autoimmune Lesions with Aging in Murine Sjögren’s Syndrome through Fas-Mediated Apoptosis

Por Ishimaru, Naozumi, Yoneda, Tomoko, Saegusa, Kaoru, Yanagi, Kumiko, Haneji, Norio, Moriyama, Keiji, Saito, Ichiro, Hayashi, Yoshio
Publicado em 2000

Novel Hybrid-Type Antimicrobial Agents Targeting the Switch Region of Bacterial RNA Polymerase

Por Yakushiji, Fumika, Miyamoto, Yuko, Kunoh, Yuki, Okamoto, Reiko, Nakaminami, Hidemasa, Yamazaki, Yuri, Noguchi, Norihisa, Hayashi, Yoshio
Publicado em 2013

Structure–Activity Relationship Studies of 3-epi-Deoxynegamycin Derivatives as Potent Readthrough Drug Candidates

Por Hamada, Keisuke, Taguchi, Akihiro, Kotake, Masaya, Aita, Suguru, Murakami, Saori, Takayama, Kentaro, Yakushiji, Fumika, Hayashi, Yoshio
Publicado no ACS Med Chem Lett (2015)

Molecular Analysis of the Human Autoantibody Response to α-Fodrin in Sjögren’s Syndrome Reveals Novel Apoptosis-Induced Specificity

Por Maruyama, Toshiaki, Saito, Ichiro, Hayashi, Yoshio, Kompfner, Elizabeth, Fox, Robert I., Burton, Dennis R., Ditzel, Henrik J.
Publicado em 2004