Novel Hybrid-Type Antimicrobial Agents Targeting the Switch Region of Bacterial RNA Polymerase

[Image: see text] The bacterial RNA polymerase (RNAP) is an ideal target for the development of antimicrobial agents against drug-resistant bacteria. Especially, the switch region within RNAP has been considered as an attractive binding site for drug discovery. Here, we designed and synthesized a se...

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Hauptverfasser: Yakushiji, Fumika, Miyamoto, Yuko, Kunoh, Yuki, Okamoto, Reiko, Nakaminami, Hidemasa, Yamazaki, Yuri, Noguchi, Norihisa, Hayashi, Yoshio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2013
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027222/
https://ncbi.nlm.nih.gov/pubmed/24900654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300350p
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