Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity

The cysteine endoprotease cathepsin S mediates degradation of the MHC class II invariant chain Ii in human and mouse antigen-presenting cells. Studies described here examine the functional significance of cathepsin S inhibition on autoantigen presentation and organ-specific autoimmune diseases in a...

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Main Authors: Saegusa, Kaoru, Ishimaru, Naozumi, Yanagi, Kumiko, Arakaki, Rieko, Ogawa, Kouichi, Saito, Ichiro, Katunuma, Nobuhiko, Hayashi, Yoshio
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2002
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC151084/
https://ncbi.nlm.nih.gov/pubmed/12163455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14682
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