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Structure–Activity Relationship Studies of 3-epi-Deoxynegamycin Derivatives as Potent Readthrough Drug Candidates

[Image: see text] (+)-Negamycin (1), a natural dipeptidic antibiotic bearing a hydrazide structure, exhibits a readthrough activity toward the nonsense mutation of the dystrophin gene and restores dystrophin expression in muscles of Duchenne muscular dystrophy model mdx mice. Herein to develop more...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Hamada, Keisuke, Taguchi, Akihiro, Kotake, Masaya, Aita, Suguru, Murakami, Saori, Takayama, Kentaro, Yakushiji, Fumika, Hayashi, Yoshio
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468409/
https://ncbi.nlm.nih.gov/pubmed/26101575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00121
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