Development of a New Benzophenone–Diketopiperazine-Type Potent Antimicrotubule Agent Possessing a 2-Pyridine Structure

[Image: see text] A new benzophenone–diketopiperazine-type potent antimicrotubule agent was developed by modifying the structure of the clinical candidate plinabulin (1). Although the right-hand imidazole ring with a branched alkyl chain at the 5-position in 1 was critical for the potency of the ant...

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Hlavní autoři: Hayashi, Yoshiki, Takeno, Haruka, Chinen, Takumi, Muguruma, Kyohei, Okuyama, Kohei, Taguchi, Akihiro, Takayama, Kentaro, Yakushiji, Fumika, Miura, Masahiko, Usui, Takeo, Hayashi, Yoshio
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190642/
https://ncbi.nlm.nih.gov/pubmed/25313318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5001883
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