Structure–Activity Relationship Study of Leucyl-3-epi-deoxynegamycin for Potent Premature Termination Codon Readthrough

[Image: see text] (+)-Negamycin, isolated from Streptomyces purpeofuscus, shows antimicrobial activity against Gram-negative bacteria and readthrough activity against nonsense mutations. Previously, we reported that two natural negamycin analogues, 5-deoxy-3-epi-negamycin and its leucine adduct, hav...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Taguchi, Akihiro, Hamada, Keisuke, Shiozuka, Masataka, Kobayashi, Misaki, Murakami, Saori, Takayama, Kentaro, Taniguchi, Atsuhiko, Usui, Takeo, Matsuda, Ryoichi, Hayashi, Yoshio
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642019/
https://ncbi.nlm.nih.gov/pubmed/29057051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00269
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