Negamycin Analogue with Readthrough-Promoting Activity as a Potential Drug Candidate for Duchenne Muscular Dystrophy

[Image: see text] A series of (+)-negamycin 1 analogues were synthesized, and their readthrough-promoting activity was evaluated for nonsense mutations in Duchenne muscular dystrophy (DMD). A structure–activity relationship study indicated that 11b was the most potent drug candidate. Immunohistochem...

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Autori principali: Taguchi, Akihiro, Nishiguchi, Shigenobu, Shiozuka, Masataka, Nomoto, Takao, Ina, Mayuko, Nojima, Shouta, Matsuda, Ryoichi, Nonomura, Yoshiaki, Kiso, Yoshiaki, Yamazaki, Yuri, Yakushiji, Fumika, Hayashi, Yoshio
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2012
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025641/
https://ncbi.nlm.nih.gov/pubmed/24900441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200245t
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