Negamycin Analogue with Readthrough-Promoting Activity as a Potential Drug Candidate for Duchenne Muscular Dystrophy

[Image: see text] A series of (+)-negamycin 1 analogues were synthesized, and their readthrough-promoting activity was evaluated for nonsense mutations in Duchenne muscular dystrophy (DMD). A structure–activity relationship study indicated that 11b was the most potent drug candidate. Immunohistochem...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Taguchi, Akihiro, Nishiguchi, Shigenobu, Shiozuka, Masataka, Nomoto, Takao, Ina, Mayuko, Nojima, Shouta, Matsuda, Ryoichi, Nonomura, Yoshiaki, Kiso, Yoshiaki, Yamazaki, Yuri, Yakushiji, Fumika, Hayashi, Yoshio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2012
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025641/
https://ncbi.nlm.nih.gov/pubmed/24900441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200245t
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items