Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA

Negamycin (NEG) is a ribosome targeting antibiotic which exhibits clinically promising activity. Its binding site and mode of action have remained unknown. We solved the structure of the Thermus thermophilus ribosome bound to mRNA and three tRNAs, in complex with NEG. The drug binds to both small an...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Polikanov, Yury S., Szal, Teresa, Jiang, Fuyan, Gupta, Pulkit, Matsuda, Ryoichi, Shiozuka, Masataka, Steitz, Thomas A., Vázquez-Laslop, Nora, Mankin, Alexander S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334386/
https://ncbi.nlm.nih.gov/pubmed/25306922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.021
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados