Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA

Negamycin (NEG) is a ribosome targeting antibiotic which exhibits clinically promising activity. Its binding site and mode of action have remained unknown. We solved the structure of the Thermus thermophilus ribosome bound to mRNA and three tRNAs, in complex with NEG. The drug binds to both small an...

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Библиографические подробности
Опубликовано в: :Mol Cell
Главные авторы: Polikanov, Yury S., Szal, Teresa, Jiang, Fuyan, Gupta, Pulkit, Matsuda, Ryoichi, Shiozuka, Masataka, Steitz, Thomas A., Vázquez-Laslop, Nora, Mankin, Alexander S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334386/
https://ncbi.nlm.nih.gov/pubmed/25306922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.021
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