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A proton wire to couple aminoacyl-tRNA accommodation and peptide bond formation on the ribosome

During peptide bond formation on the ribosome the α-amine of an aminoacyl-tRNA attacks the ester carbonyl carbon of a peptidyl-tRNA to yield a peptide lengthened by one amino acid. Although the ribosome's contribution to catalysis is predominantly entropic, the lack of high-resolution structura...

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Detalhes bibliográficos
Main Authors: Polikanov, Yury S., Steitz, Thomas A., Innis, C. Axel
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4156881/
https://ncbi.nlm.nih.gov/pubmed/25132179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2871
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