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Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome
Sarecycline is a new narrow-spectrum tetracycline-class antibiotic approved for the treatment of acne vulgaris. Tetracyclines share a common four-ring naphthacene core and inhibit protein synthesis by interacting with the 70S bacterial ribosome. Sarecycline is distinguished chemically from other tet...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7456112/ https://ncbi.nlm.nih.gov/pubmed/32817463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008671117 |
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