Distinct tRNA accommodation intermediates observed on the ribosome with the antibiotics hygromycin A and A201A

The increase in multi-drug resistant bacteria is limiting the effectiveness of currently approved antibiotics, leading to a renewed interest in antibiotics with distinct chemical scaffolds. We have solved the structures of the Thermus thermophilus 70S ribosome with A-, P- and E-site tRNAs bound, and...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Polikanov, Yury S., Starosta, Agata L., Juette, Manuel F., Altman, Roger B., Terry, Daniel S., Lu, Wanli, Burnett, Benjamin J., Dinos, George, Reynolds, Kevin A., Blanchard, Scott C., Steitz, Thomas A., Wilson, Daniel N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458074/
https://ncbi.nlm.nih.gov/pubmed/26028538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.04.014
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