Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations

af Baell, Jonathan B., Nissink, J. Willem M.
Udgivet i ACS Chem Biol (2017)

Mimicry by asx- and ST-turns of the four main types of β-turn in proteins

af Duddy, William J., Nissink, J. Willem M., Allen, Frank H., Milner-White, E. James
Udgivet 2004

A Generic Platform for Cellular Screening Against Ubiquitin Ligases

af Maculins, Timurs, Carter, Nikki, Dorval, Thierry, Hudson, Kevin, Nissink, J. Willem M., Hay, Ronald T., Alwan, Husam
Udgivet i Sci Rep (2016)

MTH1 Substrate Recognition—An Example of Specific Promiscuity

af Nissink, J. Willem M., Bista, Michal, Breed, Jason, Carter, Nikki, Embrey, Kevin, Read, Jonathan, Winter-Holt, Jon J.
Udgivet i PLoS One (2016)

Identification of Compounds That Interfere with High‐Throughput Screening Assay Technologies

af David, Laurianne, Walsh, Jarrod, Sturm, Noé, Feierberg, Isabella, Nissink, J. Willem M., Chen, Hongming, Bajorath, Jürgen, Engkvist, Ola
Udgivet i ChemMedChem (2019)

Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR

af Dahlin, Jayme L., Nissink, J. Willem M., Francis, Subhashree, Strasser, Jessica M., John, Kristen, Zhang, Zhiguo, Walters, Michael A.
Udgivet i Bioorg Med Chem Lett (2015)

PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS

af Dahlin, Jayme L., Nissink, J. Willem M., Strasser, Jessica M., Francis, Subhashree, Higgins, LeeAnn, Zhou, Hui, Zhang, Zhiguo, Walters, Michael A.
Udgivet i J Med Chem (2015)

Myc phosphorylation in its basic helix–loop–helix region destabilizes transient α-helical structures, disrupting Max and DNA binding

af Macek, Pavel, Cliff, Matthew J., Embrey, Kevin J., Holdgate, Geoffrey A., Nissink, J. Willem M., Panova, Stanislava, Waltho, Jonathan P., Davies, Rick A.
Udgivet i J Biol Chem (2018)

Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives

af Tucker, Julie A., Bennett, Neil, Brassington, Claire, Durant, Stephen T., Hassall, Giles, Holdgate, Geoff, McAlister, Mark, Nissink, J. Willem M., Truman, Caroline, Watson, Martin
Udgivet 2012

A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding

af Pflug, Alexander, Schimpl, Marianne, Nissink, J. Willem M., Overman, Ross C., Rawlins, Philip B., Truman, Caroline, Underwood, Elizabeth, Warwicker, Juli, Winter-Holt, Jon, McCoull, William
Udgivet i Biochem J (2020)

Building Bridges in a Series of Estrogen Receptor Degraders: An Application of Metathesis in Medicinal Chemistry

af Scott, James S., Breed, Jason, Carbajo, Rodrigo J., Davey, Paul R., Greenwood, Ryan, Huynh, Hoan K., Klinowska, Teresa, Morrow, Christopher J., Moss, Thomas A., Polanski, Radoslaw, Nissink, J. Willem M., Varnes, Jeffrey, Yang, Bin
Udgivet i ACS Med Chem Lett (2019)

Cellular Active N-Hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site

af Exell, Jack C., Thompson, Mark J., Finger, L. David, Shaw, Steven J., Debreczeni, Judit, Ward, Thomas A., McWhirter, Claire, Siöberg, Catrine L. B., Martinez Molina, Daniel, Mark Abbott, W., Jones, Clifford D., Nissink, J. Willem M., Durant, Stephen T., Grasby, Jane A.
Udgivet i Nat Chem Biol (2016)

Nuisance compounds in cellular assays

af Dahlin, Jayme L, Auld, Douglas S, Rothenaigner, Ina, Haney, Steve, Sexton, Jonathan Z, Nissink, J Willem M, Walsh, Jarrod, Lee, Jonathan A, Strelow, John M, Willard, Francis S, Ferrins, Lori, Baell, Jonathan B, Walters, Michael A, Hua, Bruce K, Hadian, Kamyar, Wagner, Bridget K
Udgivet i Cell Chem Biol (2021)