Identification of Compounds That Interfere with High‐Throughput Screening Assay Technologies

A significant challenge in high‐throughput screening (HTS) campaigns is the identification of assay technology interference compounds. A Compound Interfering with an Assay Technology (CIAT) gives false readouts in many assays. CIATs are often considered viable hits and investigated in follow‐up stud...

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Pubblicato in:ChemMedChem
Autori principali: David, Laurianne, Walsh, Jarrod, Sturm, Noé, Feierberg, Isabella, Nissink, J. Willem M., Chen, Hongming, Bajorath, Jürgen, Engkvist, Ola
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856845/
https://ncbi.nlm.nih.gov/pubmed/31479198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900395
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