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Application of Generative Autoencoder in De Novo Molecular Design

A major challenge in computational chemistry is the generation of novel molecular structures with desirable pharmacological and physiochemical properties. In this work, we investigate the potential use of autoencoder, a deep learning methodology, for de novo molecular design. Various generative auto...

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Bibliografski detalji
Izdano u:Mol Inform
Glavni autori: Blaschke, Thomas, Olivecrona, Marcus, Engkvist, Ola, Bajorath, Jürgen, Chen, Hongming
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836887/
https://ncbi.nlm.nih.gov/pubmed/29235269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/minf.201700123
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