PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS

[Image: see text] Significant resources in early drug discovery are spent unknowingly pursuing artifacts and promiscuous bioactive compounds, while understanding the chemical basis for these adverse behaviors often goes unexplored in pursuit of lead compounds. Nearly all the hits from our recent sul...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Dahlin, Jayme L., Nissink, J. Willem M., Strasser, Jessica M., Francis, Subhashree, Higgins, LeeAnn, Zhou, Hui, Zhang, Zhiguo, Walters, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360378/
https://ncbi.nlm.nih.gov/pubmed/25634295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5019093
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