PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS

[Image: see text] Significant resources in early drug discovery are spent unknowingly pursuing artifacts and promiscuous bioactive compounds, while understanding the chemical basis for these adverse behaviors often goes unexplored in pursuit of lead compounds. Nearly all the hits from our recent sul...

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Bibliografske podrobnosti
izdano v:J Med Chem
Main Authors: Dahlin, Jayme L., Nissink, J. Willem M., Strasser, Jessica M., Francis, Subhashree, Higgins, LeeAnn, Zhou, Hui, Zhang, Zhiguo, Walters, Michael A.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2015
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360378/
https://ncbi.nlm.nih.gov/pubmed/25634295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5019093
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