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ALARM NMR for HTS triage and chemical probe validation
Nonspecific target engagement by test compounds and purported chemical probes is a significant source of assay interference and promiscuous bioactivity in high-throughput screening (HTS) and chemical biology. Most counter-screens for thiol-reactive compounds utilize mass spectrometry or fluorescence...
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| Publicado no: | Curr Protoc Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6053072/ https://ncbi.nlm.nih.gov/pubmed/30034947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpch.35 |
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