Heme Sensor Proteins

Por Girvan, Hazel M., Munro, Andrew W.
Publicado em 2013

Unusual Cytochrome P450 Enzymes and Reactions

Por Guengerich, F. Peter, Munro, Andrew W.
Publicado em 2013

Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA.

Por McLean, Kirsty J, Scrutton, Nigel S, Munro, Andrew W
Publicado em 2003

Introduction. Quantum catalysis in enzymes: beyond the transition state theory paradigm

Por Dutton, P. Leslie, Munro, Andrew W, Scrutton, Nigel S, Sutcliffe, Michael J
Publicado em 2006

Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias

Por Butler, Christopher F., Peet, Caroline, Mason, Amy E., Voice, Michael W., Leys, David, Munro, Andrew W.
Publicado em 2013

Biofragments: An Approach towards Predicting Protein Function Using Biologically Related Fragments and its Application to Mycobacterium tuberculosis CYP126

Por Hudson, Sean A, Mashalidis, Ellene H, Bender, Andreas, McLean, Kirsty J, Munro, Andrew W, Abell, Chris
Publicado em 2014

Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series Targeting Mycobacterium tuberculosis CYP121

Por Hudson, Sean A., Surade, Sachin, Coyne, Anthony G., McLean, Kirsty J., Leys, David, Munro, Andrew W., Abell, Chris
Publicado no ChemMedChem (2013)

Characterisation of PduS, the pdu Metabolosome Corrin Reductase, and Evidence of Substructural Organisation within the Bacterial Microcompartment

Por Parsons, Joshua B., Lawrence, Andrew D., McLean, Kirsty J., Munro, Andrew W., Rigby, Stephen E. J., Warren, Martin J.
Publicado em 2010

The Structure of Mycobacterium tuberculosis CYP125: MOLECULAR BASIS FOR CHOLESTEROL BINDING IN A P450 NEEDED FOR HOST INFECTION

Por McLean, Kirsty J., Lafite, Pierre, Levy, Colin, Cheesman, Myles R., Mast, Natalia, Pikuleva, Irina A., Leys, David, Munro, Andrew W.
Publicado em 2009

A Novel Intermediate in the Reaction of Seleno CYP119 with m-Chloroperbenzoic Acid

Por Sivaramakrishnan, Santhosh, Ouellet, Hugues, Du, Jing, McLean, Kirsty J., Medzihradszky, Katalin F., Dawson, John H., Munro, Andrew W., Ortiz de Montellano, Paul R.
Publicado em 2011

Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors

Por Kavanagh, Madeline E., Gray, Janine L., Gilbert, Sophie H., Coyne, Anthony G., McLean, Kirsty J., Davis, Holly J., Munro, Andrew W., Abell, Chris
Publicado no ChemMedChem (2016)

Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN

Por Driscoll, Max D., McLean, Kirsty J., Levy, Colin, Mast, Natalia, Pikuleva, Irina A., Lafite, Pierre, Rigby, Stephen E. J., Leys, David, Munro, Andrew W.
Publicado em 2010

FdC1, a Novel Ferredoxin Protein Capable of Alternative Electron Partitioning, Increases in Conditions of Acceptor Limitation at Photosystem I

Por Voss, Ingo, Goss, Tatjana, Murozuka, Emiko, Altmann, Bianca, McLean, Kirsty J., Rigby, Stephen E. J., Munro, Andrew W., Scheibe, Renate, Hase, Toshiharu, Hanke, Guy T.
Publicado em 2011

Unusual Spectroscopic and Ligand Binding Properties of the Cytochrome P450-Flavodoxin Fusion Enzyme XplA

Por Bui, Soi H., McLean, Kirsty J., Cheesman, Myles R., Bradley, Justin M., Rigby, Stephen E. J., Levy, Colin W., Leys, David, Munro, Andrew W.
Publicado em 2012

Bacillus megaterium Has Both a Functional BluB Protein Required for DMB Synthesis and a Related Flavoprotein That Forms a Stable Radical Species

Por Collins, Hannah F., Biedendieck, Rebekka, Leech, Helen K., Gray, Michael, Escalante-Semerena, Jorge C., McLean, Kirsty J., Munro, Andrew W., Rigby, Stephen E. J., Warren, Martin J., Lawrence, Andrew D.
Publicado em 2013

Structure and Biochemical Properties of the Alkene Producing Cytochrome P450 OleT(JE) (CYP152L1) from the Jeotgalicoccus sp. 8456 Bacterium

Por Belcher, James, McLean, Kirsty J., Matthews, Sarah, Woodward, Laura S., Fisher, Karl, Rigby, Stephen E. J., Nelson, David R., Potts, Donna, Baynham, Michael T., Parker, David A., Leys, David, Munro, Andrew W.
Publicado em 2014

Strength of Axial Water Ligation in Substrate-Free Cytochrome P450s Is Isoform Dependent

Por Conner, Kip P., Schimpf, Alina M., Cruce, Alex A., McLean, Kirsty J., Munro, Andrew W., Frank, Daniel J., Krzyaniak, Matthew D., Ortiz de Montellano, Paul, Bowman, Michael K., Atkins, William M.
Publicado em 2014

Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum

Por McLean, Kirsty J., Hans, Marcus, Meijrink, Ben, van Scheppingen, Wibo B., Vollebregt, Aad, Tee, Kang Lan, van der Laan, Jan-Metske, Leys, David, Munro, Andrew W., van den Berg, Marco A.
Publicado no Proc Natl Acad Sci U S A (2015)

Catalytic Determinants of Alkene Production by the Cytochrome P450 Peroxygenase OleT(JE)

Por Matthews, Sarah, Belcher, James D., Tee, Kang Lan, Girvan, Hazel M., McLean, Kirsty J., Rigby, Stephen E. J., Levy, Colin W., Leys, David, Parker, David A., Blankley, Richard T., Munro, Andrew W.
Publicado no J Biol Chem (2017)

Structural characterization of CYP144A1 – a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis

Por Chenge, Jude, Kavanagh, Madeline E., Driscoll, Max D., McLean, Kirsty J., Young, Douglas B., Cortes, Teresa, Matak-Vinkovic, Dijana, Levy, Colin W., Rigby, Stephen E. J., Leys, David, Abell, Chris, Munro, Andrew W.
Publicado no Sci Rep (2016)