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Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series Targeting Mycobacterium tuberculosis CYP121
Freedom to merge: A combination of crystal structure examination and in silico predictions made it possible to overcome the conformational limitations of fragment merging and escape the internal strain in a series of weakly binding merged fragments that target M. tuberculosis CYP121. The insights at...
Enregistré dans:
| Publié dans: | ChemMedChem |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
WILEY‐VCH Verlag
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4281926/ https://ncbi.nlm.nih.gov/pubmed/23788280 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300219 |
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