Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

[Image: see text] The essential enzyme CYP121 is a target for drug development against antibiotic resistant strains of Mycobacterium tuberculosis. A triazol-1-yl phenol fragment 1 was identified to bind to CYP121 using a cascade of biophysical assays. Synthetic merging and optimization of 1 produced...

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Vydáno v:J Med Chem
Hlavní autoři: Kavanagh, Madeline E., Coyne, Anthony G., McLean, Kirsty J., James, Guy G., Levy, Colin W., Marino, Leonardo B., de Carvalho, Luiz Pedro S., Chan, Daniel S. H., Hudson, Sean A., Surade, Sachin, Leys, David, Munro, Andrew W., Abell, Chris
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2016
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835159/
https://ncbi.nlm.nih.gov/pubmed/27002486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00007
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