Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

[Image: see text] The essential enzyme CYP121 is a target for drug development against antibiotic resistant strains of Mycobacterium tuberculosis. A triazol-1-yl phenol fragment 1 was identified to bind to CYP121 using a cascade of biophysical assays. Synthetic merging and optimization of 1 produced...

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Publicat a:J Med Chem
Autors principals: Kavanagh, Madeline E., Coyne, Anthony G., McLean, Kirsty J., James, Guy G., Levy, Colin W., Marino, Leonardo B., de Carvalho, Luiz Pedro S., Chan, Daniel S. H., Hudson, Sean A., Surade, Sachin, Leys, David, Munro, Andrew W., Abell, Chris
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2016
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835159/
https://ncbi.nlm.nih.gov/pubmed/27002486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00007
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