Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

[Image: see text] The essential enzyme CYP121 is a target for drug development against antibiotic resistant strains of Mycobacterium tuberculosis. A triazol-1-yl phenol fragment 1 was identified to bind to CYP121 using a cascade of biophysical assays. Synthetic merging and optimization of 1 produced...

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Détails bibliographiques
Publié dans:J Med Chem
Auteurs principaux: Kavanagh, Madeline E., Coyne, Anthony G., McLean, Kirsty J., James, Guy G., Levy, Colin W., Marino, Leonardo B., de Carvalho, Luiz Pedro S., Chan, Daniel S. H., Hudson, Sean A., Surade, Sachin, Leys, David, Munro, Andrew W., Abell, Chris
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2016
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835159/
https://ncbi.nlm.nih.gov/pubmed/27002486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00007
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