Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN

The Mycobacterium tuberculosis cytochrome P450 enzyme CYP142 is encoded in a large gene cluster involved in metabolism of host cholesterol. CYP142 was expressed and purified as a soluble, low spin P450 hemoprotein. CYP142 binds tightly to cholesterol and its oxidized derivative cholest-4-en-3-one, w...

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Hlavní autoři: Driscoll, Max D., McLean, Kirsty J., Levy, Colin, Mast, Natalia, Pikuleva, Irina A., Lafite, Pierre, Rigby, Stephen E. J., Leys, David, Munro, Andrew W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992261/
https://ncbi.nlm.nih.gov/pubmed/20889498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.164293
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