Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity

Cytochrome P450 46A1 (CYP46A1) is a microsomal enzyme and cholesterol 24-hydroxylase that controls cholesterol elimination from the brain. This P450 is also a potential target for Alzheimer disease because it can be activated pharmacologically by some marketed drugs, as exemplified by efavirenz, the...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Anderson, Kyle W., Mast, Natalia, Hudgens, Jeffrey W., Lin, Joseph B., Turko, Illarion V., Pikuleva, Irina A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Enzymology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882454/
https://ncbi.nlm.nih.gov/pubmed/27056331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.723577
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