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CYP46A1-dependent and independent effects of efavirenz treatment

Cholesterol excess in the brain is mainly disposed via cholesterol 24-hydroxylation catalysed by cytochrome P450 46A1, a CNS-specific enzyme. Cytochrome P450 46A1 is emerging as a promising therapeutic target for various brain diseases with both enzyme activation and inhibition having therapeutic po...

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書目詳細資料
發表在:Brain Commun
Main Authors: Mast, Natalia, El-Darzi, Nicole, Petrov, Alexey M, Li, Young, Pikuleva, Irina A
格式: Artigo
語言:Inglês
出版: Oxford University Press 2020
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7713991/
https://ncbi.nlm.nih.gov/pubmed/33305262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcaa180
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