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CYP46A1-dependent and independent effects of efavirenz treatment
Cholesterol excess in the brain is mainly disposed via cholesterol 24-hydroxylation catalysed by cytochrome P450 46A1, a CNS-specific enzyme. Cytochrome P450 46A1 is emerging as a promising therapeutic target for various brain diseases with both enzyme activation and inhibition having therapeutic po...
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| Pubblicato in: | Brain Commun |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7713991/ https://ncbi.nlm.nih.gov/pubmed/33305262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcaa180 |
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