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Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases

Cholesterol 24-hydroxylation is the major mechanism for cholesterol removal from the brain and the reaction catalyzed by cytochrome P450 46A1 (CYP46A1), a CNS-specific enzyme. This review describes CYP46A1 in the context of cholesterol homeostasis in the brain and summarizes available experimental d...

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Detalhes bibliográficos
Publicado no:Neurotherapeutics
Main Authors: Petrov, Alexey M., Pikuleva, Irina A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694357/
https://ncbi.nlm.nih.gov/pubmed/31001737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-019-00731-6
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