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Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases
Cholesterol 24-hydroxylation is the major mechanism for cholesterol removal from the brain and the reaction catalyzed by cytochrome P450 46A1 (CYP46A1), a CNS-specific enzyme. This review describes CYP46A1 in the context of cholesterol homeostasis in the brain and summarizes available experimental d...
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| Veröffentlicht in: | Neurotherapeutics |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer International Publishing
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6694357/ https://ncbi.nlm.nih.gov/pubmed/31001737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-019-00731-6 |
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