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In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds
Cytochrome P450 46A1 (CYP46A1, cholesterol 24-hydroxylase) is the enzyme responsible for the majority of cholesterol elimination from the brain. Previously, we found that the anti-HIV drug efavirenz (EFV) can pharmacologically activate CYP46A1 in mice. Herein, we investigated whether CYP46A1 could a...
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| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5546033/ https://ncbi.nlm.nih.gov/pubmed/28642370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.794909 |
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