In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds

Cytochrome P450 46A1 (CYP46A1, cholesterol 24-hydroxylase) is the enzyme responsible for the majority of cholesterol elimination from the brain. Previously, we found that the anti-HIV drug efavirenz (EFV) can pharmacologically activate CYP46A1 in mice. Herein, we investigated whether CYP46A1 could a...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Mast, Natalia, Anderson, Kyle W., Johnson, Kevin M., Phan, Thanh T. N., Guengerich, F. Peter, Pikuleva, Irina A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2017
Konular:
Enzymology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546033/
https://ncbi.nlm.nih.gov/pubmed/28642370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.794909
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