The Structure of Mycobacterium tuberculosis CYP125: MOLECULAR BASIS FOR CHOLESTEROL BINDING IN A P450 NEEDED FOR HOST INFECTION

We report characterization and the crystal structure of the Mycobacterium tuberculosis cytochrome P450 CYP125, a P450 implicated in metabolism of host cholesterol and essential for establishing infection in mice. CYP125 is purified in a high spin form and undergoes both type I and II spectral shifts...

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Autors principals: McLean, Kirsty J., Lafite, Pierre, Levy, Colin, Cheesman, Myles R., Mast, Natalia, Pikuleva, Irina A., Leys, David, Munro, Andrew W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Enzyme Catalysis and Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790982/
https://ncbi.nlm.nih.gov/pubmed/19846552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032706
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