Mycobacterial Cytochrome P450 125 (Cyp125) Catalyzes the Terminal Hydroxylation of C27 Steroids

Cyp125 (Rv3545c), a cytochrome P450, is encoded as part of the cholesterol degradation gene cluster conserved among members of the Mycobacterium tuberculosis complex. This enzyme has been implicated in mycobacterial pathogenesis, and a homologue initiates cholesterol catabolism in the soil actinomyc...

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Detalhes bibliográficos
Main Authors: Capyk, Jenna K., Kalscheuer, Rainer, Stewart, Gordon R., Liu, Jie, Kwon, Hyukin, Zhao, Rafael, Okamoto, Sachi, Jacobs, William R., Eltis, Lindsay D., Mohn, William W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790983/
https://ncbi.nlm.nih.gov/pubmed/19846551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072132
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