Hydroxylation of Antitubercular Drug Candidate, SQ109, by Mycobacterial Cytochrome P450

Spreading of the multidrug-resistant (MDR) strains of the one of the most harmful pathogen Mycobacterium tuberculosis (Mtb) generates the need for new effective drugs. SQ109 showed activity against resistant Mtb and already advanced to Phase II/III clinical trials. Fast SQ109 degradation is attribut...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Bukhdruker, Sergey, Varaksa, Tatsiana, Grabovec, Irina, Marin, Egor, Shabunya, Polina, Kadukova, Maria, Grudinin, Sergei, Kavaleuski, Anton, Gusach, Anastasiia, Gilep, Andrei, Borshchevskiy, Valentin, Strushkevich, Natallia
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589583/
https://ncbi.nlm.nih.gov/pubmed/33081390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21207683
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