Hydroxylation of Antitubercular Drug Candidate, SQ109, by Mycobacterial Cytochrome P450

Spreading of the multidrug-resistant (MDR) strains of the one of the most harmful pathogen Mycobacterium tuberculosis (Mtb) generates the need for new effective drugs. SQ109 showed activity against resistant Mtb and already advanced to Phase II/III clinical trials. Fast SQ109 degradation is attribut...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Bukhdruker, Sergey, Varaksa, Tatsiana, Grabovec, Irina, Marin, Egor, Shabunya, Polina, Kadukova, Maria, Grudinin, Sergei, Kavaleuski, Anton, Gusach, Anastasiia, Gilep, Andrei, Borshchevskiy, Valentin, Strushkevich, Natallia
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589583/
https://ncbi.nlm.nih.gov/pubmed/33081390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21207683
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires