Human Lanosterol 14-Alpha Demethylase (CYP51A1) Is a Putative Target for Natural Flavonoid Luteolin 7,3′-Disulfate

Widespread pathologies such as atherosclerosis, metabolic syndrome and cancer are associated with dysregulation of sterol biosynthesis and metabolism. Cholesterol modulates the signaling pathways of neoplastic transformation and tumor progression. Lanosterol 14-alpha demethylase (cytochrome P450(51)...

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Bibliografiska uppgifter
I publikationen:Molecules
Huvudupphovsmän: Kaluzhskiy, Leonid, Ershov, Pavel, Yablokov, Evgeniy, Shkel, Tatsiana, Grabovec, Irina, Mezentsev, Yuri, Gnedenko, Oksana, Usanov, Sergey, Shabunya, Polina, Fatykhava, Sviatlana, Popov, Alexander, Artyukov, Aleksandr, Styshova, Olga, Gilep, Andrei, Strushkevich, Natallia, Ivanov, Alexis
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2021
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070018/
https://ncbi.nlm.nih.gov/pubmed/33924405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26082237
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