Human Lanosterol 14-Alpha Demethylase (CYP51A1) Is a Putative Target for Natural Flavonoid Luteolin 7,3′-Disulfate

Widespread pathologies such as atherosclerosis, metabolic syndrome and cancer are associated with dysregulation of sterol biosynthesis and metabolism. Cholesterol modulates the signaling pathways of neoplastic transformation and tumor progression. Lanosterol 14-alpha demethylase (cytochrome P450(51)...

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Publicat a:Molecules
Autors principals: Kaluzhskiy, Leonid, Ershov, Pavel, Yablokov, Evgeniy, Shkel, Tatsiana, Grabovec, Irina, Mezentsev, Yuri, Gnedenko, Oksana, Usanov, Sergey, Shabunya, Polina, Fatykhava, Sviatlana, Popov, Alexander, Artyukov, Aleksandr, Styshova, Olga, Gilep, Andrei, Strushkevich, Natallia, Ivanov, Alexis
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070018/
https://ncbi.nlm.nih.gov/pubmed/33924405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26082237
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