Hydroxylation of Antitubercular Drug Candidate, SQ109, by Mycobacterial Cytochrome P450

Spreading of the multidrug-resistant (MDR) strains of the one of the most harmful pathogen Mycobacterium tuberculosis (Mtb) generates the need for new effective drugs. SQ109 showed activity against resistant Mtb and already advanced to Phase II/III clinical trials. Fast SQ109 degradation is attribut...

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Publicado en:Int J Mol Sci
Autores principales: Bukhdruker, Sergey, Varaksa, Tatsiana, Grabovec, Irina, Marin, Egor, Shabunya, Polina, Kadukova, Maria, Grudinin, Sergei, Kavaleuski, Anton, Gusach, Anastasiia, Gilep, Andrei, Borshchevskiy, Valentin, Strushkevich, Natallia
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589583/
https://ncbi.nlm.nih.gov/pubmed/33081390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21207683
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