Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN

The Mycobacterium tuberculosis cytochrome P450 enzyme CYP142 is encoded in a large gene cluster involved in metabolism of host cholesterol. CYP142 was expressed and purified as a soluble, low spin P450 hemoprotein. CYP142 binds tightly to cholesterol and its oxidized derivative cholest-4-en-3-one, w...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Driscoll, Max D., McLean, Kirsty J., Levy, Colin, Mast, Natalia, Pikuleva, Irina A., Lafite, Pierre, Rigby, Stephen E. J., Leys, David, Munro, Andrew W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992261/
https://ncbi.nlm.nih.gov/pubmed/20889498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.164293
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi