Biofilm GL261 mouse model HUVEC SonoCloud SonoTran Particles acoustic droplet vaporization cancer cationic microbubble cavitation cavitation nuclei cetuximab checkpoint inhibitor contrast-enhanced ultrasound drug delivery endothelial cells focused ultrasound gemcitabine gene therapy glioblastoma head and neck cancer immune checkpoint inhibitors immunotherapy inertial cavitation inner ear intravascular ultrasound large animal cancer model lonidamine metabolomics metformin miRNA delivery