Preventing and exploiting the oncogenic potential of integrating gene vectors

af Modlich, Ute, Baum, Christopher
Udgivet 2009

Efficiency and Safety of O(6)-Methylguanine DNA Methyltransferase (MGMT(P140K))-Mediated In Vivo Selection in a Humanized Mouse Model

af Phaltane, Ruhi, Haemmerle, Reinhard, Rothe, Michael, Modlich, Ute, Moritz, Thomas
Udgivet 2014

Comparison of Different Cytokine Conditions Reveals Resveratrol as a New Molecule for Ex Vivo Cultivation of Cord Blood-Derived Hematopoietic Stem Cells

af Heinz, Niels, Ehrnström, Birgitta, Schambach, Axel, Schwarzer, Adrian, Modlich, Ute, Schiedlmeier, Bernhard
Udgivet i Stem Cells Transl Med (2015)

Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model

af Haemmerle, Reinhard, Phaltane, Ruhi, Rothe, Michael, Schröder, Simon, Schambach, Axel, Moritz, Thomas, Modlich, Ute
Udgivet 2014

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

af Modlich, Ute, Bohne, Jens, Schmidt, Manfred, von Kalle, Christof, Knöss, Sabine, Schambach, Axel, Baum, Christopher
Udgivet 2006

Gene therapy cures the anemia and lethal bone marrow failure in a mouse model of RPS19-deficient Diamond-Blackfan anemia

af Jaako, Pekka, Debnath, Shubhranshu, Olsson, Karin, Modlich, Ute, Rothe, Michael, Schambach, Axel, Flygare, Johan, Karlsson, Stefan
Udgivet i Haematologica (2014)

Evaluating a Ligation-Mediated PCR and Pyrosequencing Method for the Detection of Clonal Contribution in Polyclonal Retrovirally Transduced Samples

af Brugman, Martijn H., Suerth, Julia D., Rothe, Michael, Suerbaum, Sebastian, Schambach, Axel, Modlich, Ute, Kustikova, Olga, Baum, Christopher
Udgivet 2013

Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance

af Kohlscheen, Saskia, Wintterle, Sabine, Schwarzer, Adrian, Kamp, Christel, Brugman, Martijn H., Breuer, Daniel C., Büsche, Guntram, Baum, Christopher, Modlich, Ute
Udgivet i PLoS One (2015)

Genotoxic Potential of Lineage-specific Lentivirus Vectors Carrying the β-Globin Locus Control Region

af Arumugam, Paritha I, Higashimoto, Tomoyasu, Urbinati, Fabrizia, Modlich, Ute, Nestheide, Shawna, Xia, Ping, Fox, Catherine, Corsinotti, Andrea, Baum, Christopher, Malik, Punam
Udgivet 2009

Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy

af El Ashkar, Sara, Van Looveren, Dominique, Schenk, Franziska, Vranckx, Lenard S., Demeulemeester, Jonas, De Rijck, Jan, Debyser, Zeger, Modlich, Ute, Gijsbers, Rik
Udgivet i Mol Ther Nucleic Acids (2017)

Gene Therapy of Mpl Deficiency: Challenging Balance Between Leukemia and Pancytopenia

af Wicke, Daniel C, Meyer, Johann, Buesche, Guntram, Heckl, Dirk, Kreipe, Hans, Li, Zhixiong, Welte, Karl H, Ballmaier, Matthias, Baum, Christopher, Modlich, Ute
Udgivet 2009

Hematopoietic Stem Cell Transplantation Restores Naïve T-Cell Populations in Atm-Deficient Mice and in Preemptively Treated Patients With Ataxia-Telangiectasia

af Duecker, Ruth, Baer, Patrick C., Buecker, Aileen, Huenecke, Sabine, Pfeffermann, Lisa-Marie, Modlich, Ute, Bakhtiar, Shahrzad, Bader, Peter, Zielen, Stefan, Schubert, Ralf
Udgivet i Front Immunol (2019)

High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia

af Müller, Stephan, Bexte, Tobias, Gebel, Veronika, Kalensee, Franziska, Stolzenberg, Eva, Hartmann, Jessica, Koehl, Ulrike, Schambach, Axel, Wels, Winfried S., Modlich, Ute, Ullrich, Evelyn
Udgivet i Front Immunol (2020)

HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells

af Pilat, Sandra, Carotta, Sebastian, Schiedlmeier, Bernhard, Kamino, Kenji, Mairhofer, Andreas, Will, Elke, Modlich, Ute, Steinlein, Peter, Ostertag, Wolfram, Baum, Christopher, Beug, Hartmut, Klump, Hannes
Udgivet 2005

Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Murine Leukemia

af Heckl, Dirk, Schwarzer, Adrian, Haemmerle, Reinhard, Steinemann, Doris, Rudolph, Cornelia, Skawran, Britta, Knoess, Sabine, Krause, Johanna, Li, Zhixiong, Schlegelberger, Brigitte, Baum, Christopher, Modlich, Ute
Udgivet 2012

Forming megakaryocytes from murine induced pluripotent stem cells by the inducible overexpression of supporting factors

af Cullmann, Katharina, Jahn, Magdalena, Spindler, Markus, Schenk, Franziska, Manukjan, Georgi, Mucci, Adele, Steinemann, Doris, Boller, Klaus, Schulze, Harald, Bender, Markus, Moritz, Thomas, Modlich, Ute
Udgivet i Res Pract Thromb Haemost (2020)

Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors

af Modlich, Ute, Navarro, Susana, Zychlinski, Daniela, Maetzig, Tobias, Knoess, Sabine, Brugman, Martijn H., Schambach, Axel, Charrier, Sabine, Galy, Anne, Thrasher, Adrian J., Bueren, Juan, Baum, Christopher
Udgivet 2009

Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity

af Suerth, Julia D, Maetzig, Tobias, Brugman, Martijn H, Heinz, Niels, Appelt, Jens-Uwe, Kaufmann, Kerstin B, Schmidt, Manfred, Grez, Manuel, Modlich, Ute, Baum, Christopher, Schambach, Axel
Udgivet 2012

Lentiviral Gene Therapy Using Cellular Promoters Cures Type 1 Gaucher Disease in Mice

af Dahl, Maria, Doyle, Alexander, Olsson, Karin, Månsson, Jan-Eric, Marques, André R A, Mirzaian, Mina, Aerts, Johannes M, Ehinger, Mats, Rothe, Michael, Modlich, Ute, Schambach, Axel, Karlsson, Stefan
Udgivet i Mol Ther (2015)

In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

af Pfeiffer, Anett, Thalheimer, Frederic B, Hartmann, Sylvia, Frank, Annika M, Bender, Ruben R, Danisch, Simon, Costa, Caroline, Wels, Winfried S, Modlich, Ute, Stripecke, Renata, Verhoeyen, Els, Buchholz, Christian J
Udgivet i EMBO Mol Med (2018)