Preventing and exploiting the oncogenic potential of integrating gene vectors

بواسطة Modlich, Ute, Baum, Christopher
منشور في 2009

Efficiency and Safety of O(6)-Methylguanine DNA Methyltransferase (MGMT(P140K))-Mediated In Vivo Selection in a Humanized Mouse Model

بواسطة Phaltane, Ruhi, Haemmerle, Reinhard, Rothe, Michael, Modlich, Ute, Moritz, Thomas
منشور في 2014

Comparison of Different Cytokine Conditions Reveals Resveratrol as a New Molecule for Ex Vivo Cultivation of Cord Blood-Derived Hematopoietic Stem Cells

بواسطة Heinz, Niels, Ehrnström, Birgitta, Schambach, Axel, Schwarzer, Adrian, Modlich, Ute, Schiedlmeier, Bernhard
الحاوية / القاعدة Stem Cells Transl Med (2015)

Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model

بواسطة Haemmerle, Reinhard, Phaltane, Ruhi, Rothe, Michael, Schröder, Simon, Schambach, Axel, Moritz, Thomas, Modlich, Ute
منشور في 2014

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

بواسطة Modlich, Ute, Bohne, Jens, Schmidt, Manfred, von Kalle, Christof, Knöss, Sabine, Schambach, Axel, Baum, Christopher
منشور في 2006

Gene therapy cures the anemia and lethal bone marrow failure in a mouse model of RPS19-deficient Diamond-Blackfan anemia

بواسطة Jaako, Pekka, Debnath, Shubhranshu, Olsson, Karin, Modlich, Ute, Rothe, Michael, Schambach, Axel, Flygare, Johan, Karlsson, Stefan
الحاوية / القاعدة Haematologica (2014)

Evaluating a Ligation-Mediated PCR and Pyrosequencing Method for the Detection of Clonal Contribution in Polyclonal Retrovirally Transduced Samples

بواسطة Brugman, Martijn H., Suerth, Julia D., Rothe, Michael, Suerbaum, Sebastian, Schambach, Axel, Modlich, Ute, Kustikova, Olga, Baum, Christopher
منشور في 2013

Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance

بواسطة Kohlscheen, Saskia, Wintterle, Sabine, Schwarzer, Adrian, Kamp, Christel, Brugman, Martijn H., Breuer, Daniel C., Büsche, Guntram, Baum, Christopher, Modlich, Ute
الحاوية / القاعدة PLoS One (2015)

Genotoxic Potential of Lineage-specific Lentivirus Vectors Carrying the β-Globin Locus Control Region

بواسطة Arumugam, Paritha I, Higashimoto, Tomoyasu, Urbinati, Fabrizia, Modlich, Ute, Nestheide, Shawna, Xia, Ping, Fox, Catherine, Corsinotti, Andrea, Baum, Christopher, Malik, Punam
منشور في 2009

Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy

بواسطة El Ashkar, Sara, Van Looveren, Dominique, Schenk, Franziska, Vranckx, Lenard S., Demeulemeester, Jonas, De Rijck, Jan, Debyser, Zeger, Modlich, Ute, Gijsbers, Rik
الحاوية / القاعدة Mol Ther Nucleic Acids (2017)

Gene Therapy of Mpl Deficiency: Challenging Balance Between Leukemia and Pancytopenia

بواسطة Wicke, Daniel C, Meyer, Johann, Buesche, Guntram, Heckl, Dirk, Kreipe, Hans, Li, Zhixiong, Welte, Karl H, Ballmaier, Matthias, Baum, Christopher, Modlich, Ute
منشور في 2009

Hematopoietic Stem Cell Transplantation Restores Naïve T-Cell Populations in Atm-Deficient Mice and in Preemptively Treated Patients With Ataxia-Telangiectasia

بواسطة Duecker, Ruth, Baer, Patrick C., Buecker, Aileen, Huenecke, Sabine, Pfeffermann, Lisa-Marie, Modlich, Ute, Bakhtiar, Shahrzad, Bader, Peter, Zielen, Stefan, Schubert, Ralf
الحاوية / القاعدة Front Immunol (2019)

High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia

بواسطة Müller, Stephan, Bexte, Tobias, Gebel, Veronika, Kalensee, Franziska, Stolzenberg, Eva, Hartmann, Jessica, Koehl, Ulrike, Schambach, Axel, Wels, Winfried S., Modlich, Ute, Ullrich, Evelyn
الحاوية / القاعدة Front Immunol (2020)

HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells

بواسطة Pilat, Sandra, Carotta, Sebastian, Schiedlmeier, Bernhard, Kamino, Kenji, Mairhofer, Andreas, Will, Elke, Modlich, Ute, Steinlein, Peter, Ostertag, Wolfram, Baum, Christopher, Beug, Hartmut, Klump, Hannes
منشور في 2005

Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Murine Leukemia

بواسطة Heckl, Dirk, Schwarzer, Adrian, Haemmerle, Reinhard, Steinemann, Doris, Rudolph, Cornelia, Skawran, Britta, Knoess, Sabine, Krause, Johanna, Li, Zhixiong, Schlegelberger, Brigitte, Baum, Christopher, Modlich, Ute
منشور في 2012

Forming megakaryocytes from murine induced pluripotent stem cells by the inducible overexpression of supporting factors

بواسطة Cullmann, Katharina, Jahn, Magdalena, Spindler, Markus, Schenk, Franziska, Manukjan, Georgi, Mucci, Adele, Steinemann, Doris, Boller, Klaus, Schulze, Harald, Bender, Markus, Moritz, Thomas, Modlich, Ute
الحاوية / القاعدة Res Pract Thromb Haemost (2020)

Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors

بواسطة Modlich, Ute, Navarro, Susana, Zychlinski, Daniela, Maetzig, Tobias, Knoess, Sabine, Brugman, Martijn H., Schambach, Axel, Charrier, Sabine, Galy, Anne, Thrasher, Adrian J., Bueren, Juan, Baum, Christopher
منشور في 2009

Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity

بواسطة Suerth, Julia D, Maetzig, Tobias, Brugman, Martijn H, Heinz, Niels, Appelt, Jens-Uwe, Kaufmann, Kerstin B, Schmidt, Manfred, Grez, Manuel, Modlich, Ute, Baum, Christopher, Schambach, Axel
منشور في 2012

Lentiviral Gene Therapy Using Cellular Promoters Cures Type 1 Gaucher Disease in Mice

بواسطة Dahl, Maria, Doyle, Alexander, Olsson, Karin, Månsson, Jan-Eric, Marques, André R A, Mirzaian, Mina, Aerts, Johannes M, Ehinger, Mats, Rothe, Michael, Modlich, Ute, Schambach, Axel, Karlsson, Stefan
الحاوية / القاعدة Mol Ther (2015)

In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

بواسطة Pfeiffer, Anett, Thalheimer, Frederic B, Hartmann, Sylvia, Frank, Annika M, Bender, Ruben R, Danisch, Simon, Costa, Caroline, Wels, Winfried S, Modlich, Ute, Stripecke, Renata, Verhoeyen, Els, Buchholz, Christian J
الحاوية / القاعدة EMBO Mol Med (2018)