Preventing and exploiting the oncogenic potential of integrating gene vectors

Por Modlich, Ute, Baum, Christopher
Publicado em 2009

Efficiency and Safety of O(6)-Methylguanine DNA Methyltransferase (MGMT(P140K))-Mediated In Vivo Selection in a Humanized Mouse Model

Por Phaltane, Ruhi, Haemmerle, Reinhard, Rothe, Michael, Modlich, Ute, Moritz, Thomas
Publicado em 2014

Comparison of Different Cytokine Conditions Reveals Resveratrol as a New Molecule for Ex Vivo Cultivation of Cord Blood-Derived Hematopoietic Stem Cells

Por Heinz, Niels, Ehrnström, Birgitta, Schambach, Axel, Schwarzer, Adrian, Modlich, Ute, Schiedlmeier, Bernhard
Publicado no Stem Cells Transl Med (2015)

Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model

Por Haemmerle, Reinhard, Phaltane, Ruhi, Rothe, Michael, Schröder, Simon, Schambach, Axel, Moritz, Thomas, Modlich, Ute
Publicado em 2014

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

Por Modlich, Ute, Bohne, Jens, Schmidt, Manfred, von Kalle, Christof, Knöss, Sabine, Schambach, Axel, Baum, Christopher
Publicado em 2006

Gene therapy cures the anemia and lethal bone marrow failure in a mouse model of RPS19-deficient Diamond-Blackfan anemia

Por Jaako, Pekka, Debnath, Shubhranshu, Olsson, Karin, Modlich, Ute, Rothe, Michael, Schambach, Axel, Flygare, Johan, Karlsson, Stefan
Publicado no Haematologica (2014)

Evaluating a Ligation-Mediated PCR and Pyrosequencing Method for the Detection of Clonal Contribution in Polyclonal Retrovirally Transduced Samples

Por Brugman, Martijn H., Suerth, Julia D., Rothe, Michael, Suerbaum, Sebastian, Schambach, Axel, Modlich, Ute, Kustikova, Olga, Baum, Christopher
Publicado em 2013

Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance

Por Kohlscheen, Saskia, Wintterle, Sabine, Schwarzer, Adrian, Kamp, Christel, Brugman, Martijn H., Breuer, Daniel C., Büsche, Guntram, Baum, Christopher, Modlich, Ute
Publicado no PLoS One (2015)

Genotoxic Potential of Lineage-specific Lentivirus Vectors Carrying the β-Globin Locus Control Region

Por Arumugam, Paritha I, Higashimoto, Tomoyasu, Urbinati, Fabrizia, Modlich, Ute, Nestheide, Shawna, Xia, Ping, Fox, Catherine, Corsinotti, Andrea, Baum, Christopher, Malik, Punam
Publicado em 2009

Engineering Next-Generation BET-Independent MLV Vectors for Safer Gene Therapy

Por El Ashkar, Sara, Van Looveren, Dominique, Schenk, Franziska, Vranckx, Lenard S., Demeulemeester, Jonas, De Rijck, Jan, Debyser, Zeger, Modlich, Ute, Gijsbers, Rik
Publicado no Mol Ther Nucleic Acids (2017)

Gene Therapy of Mpl Deficiency: Challenging Balance Between Leukemia and Pancytopenia

Por Wicke, Daniel C, Meyer, Johann, Buesche, Guntram, Heckl, Dirk, Kreipe, Hans, Li, Zhixiong, Welte, Karl H, Ballmaier, Matthias, Baum, Christopher, Modlich, Ute
Publicado em 2009

Hematopoietic Stem Cell Transplantation Restores Naïve T-Cell Populations in Atm-Deficient Mice and in Preemptively Treated Patients With Ataxia-Telangiectasia

Por Duecker, Ruth, Baer, Patrick C., Buecker, Aileen, Huenecke, Sabine, Pfeffermann, Lisa-Marie, Modlich, Ute, Bakhtiar, Shahrzad, Bader, Peter, Zielen, Stefan, Schubert, Ralf
Publicado no Front Immunol (2019)

High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia

Por Müller, Stephan, Bexte, Tobias, Gebel, Veronika, Kalensee, Franziska, Stolzenberg, Eva, Hartmann, Jessica, Koehl, Ulrike, Schambach, Axel, Wels, Winfried S., Modlich, Ute, Ullrich, Evelyn
Publicado no Front Immunol (2020)

HOXB4 enforces equivalent fates of ES-cell-derived and adult hematopoietic cells

Por Pilat, Sandra, Carotta, Sebastian, Schiedlmeier, Bernhard, Kamino, Kenji, Mairhofer, Andreas, Will, Elke, Modlich, Ute, Steinlein, Peter, Ostertag, Wolfram, Baum, Christopher, Beug, Hartmut, Klump, Hannes
Publicado em 2005

Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Murine Leukemia

Por Heckl, Dirk, Schwarzer, Adrian, Haemmerle, Reinhard, Steinemann, Doris, Rudolph, Cornelia, Skawran, Britta, Knoess, Sabine, Krause, Johanna, Li, Zhixiong, Schlegelberger, Brigitte, Baum, Christopher, Modlich, Ute
Publicado em 2012

Forming megakaryocytes from murine induced pluripotent stem cells by the inducible overexpression of supporting factors

Por Cullmann, Katharina, Jahn, Magdalena, Spindler, Markus, Schenk, Franziska, Manukjan, Georgi, Mucci, Adele, Steinemann, Doris, Boller, Klaus, Schulze, Harald, Bender, Markus, Moritz, Thomas, Modlich, Ute
Publicado no Res Pract Thromb Haemost (2020)

Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors

Por Modlich, Ute, Navarro, Susana, Zychlinski, Daniela, Maetzig, Tobias, Knoess, Sabine, Brugman, Martijn H., Schambach, Axel, Charrier, Sabine, Galy, Anne, Thrasher, Adrian J., Bueren, Juan, Baum, Christopher
Publicado em 2009

Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity

Por Suerth, Julia D, Maetzig, Tobias, Brugman, Martijn H, Heinz, Niels, Appelt, Jens-Uwe, Kaufmann, Kerstin B, Schmidt, Manfred, Grez, Manuel, Modlich, Ute, Baum, Christopher, Schambach, Axel
Publicado em 2012

Lentiviral Gene Therapy Using Cellular Promoters Cures Type 1 Gaucher Disease in Mice

Por Dahl, Maria, Doyle, Alexander, Olsson, Karin, Månsson, Jan-Eric, Marques, André R A, Mirzaian, Mina, Aerts, Johannes M, Ehinger, Mats, Rothe, Michael, Modlich, Ute, Schambach, Axel, Karlsson, Stefan
Publicado no Mol Ther (2015)

In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

Por Pfeiffer, Anett, Thalheimer, Frederic B, Hartmann, Sylvia, Frank, Annika M, Bender, Ruben R, Danisch, Simon, Costa, Caroline, Wels, Winfried S, Modlich, Ute, Stripecke, Renata, Verhoeyen, Els, Buchholz, Christian J
Publicado no EMBO Mol Med (2018)