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Efficiency and Safety of O(6)-Methylguanine DNA Methyltransferase (MGMT(P140K))-Mediated In Vivo Selection in a Humanized Mouse Model
Efficient O(6)-methylguanine DNA methyltransferase (MGMT(P140K))-mediated myeloprotection and in vivo selection have been demonstrated in numerous animal models and most recently in a phase I clinical study in glioblastoma patients. However, this strategy may augment the genotoxic risk of integratin...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Mary Ann Liebert, Inc.
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3922287/ https://ncbi.nlm.nih.gov/pubmed/24218991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.171 |
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