Reciprocal Relationship between O(6)-Methylguanine-DNA Methyltransferase P140K Expression Level and Chemoprotection of Hematopoietic Stem Cells

Retroviral-mediated delivery of the P140K mutant O(6)-methylguanine-DNA methyltransferase (MGMT(P140K)) into hematopoietic stem cells (HSC) has been proposed as a means to protect against dose-limiting myelosuppressive toxicity ensuing from chemotherapy combining O(6)-alkylating agents (e.g., temozo...

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Publicado no:Cancer Res
Main Authors: Milsom, Michael D., Jerabek-Willemsen, Moran, Harris, Chad E., Schambach, Axel, Broun, Emily, Bailey, Jeff, Jansen, Michael, Schleimer, David, Nattamai, Kalpana, Wilhelm, Jamie, Watson, Amanda, Geiger, Hartmut, Margison, Geoffrey P., Moritz, Thomas, Baum, Christopher, Thomale, Jürgen, Williams, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337843/
https://ncbi.nlm.nih.gov/pubmed/18676840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0320
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