Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

Retroviral vectors with long terminal repeats (LTRs), which contain strong enhancer/promoter sequences at both ends of their genome, are widely used for stable gene transfer into hematopoietic cells. However, recent clinical data and mouse models point to insertional activation of cellular proto-onc...

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Detaylı Bibliyografya
Asıl Yazarlar: Modlich, Ute, Bohne, Jens, Schmidt, Manfred, von Kalle, Christof, Knöss, Sabine, Schambach, Axel, Baum, Christopher
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: © 2006 by The American Society of Hematology 2006
Konular:
Gene Therapy
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895590/
https://ncbi.nlm.nih.gov/pubmed/16825499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-08-024976
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