Alpharetroviral Self-inactivating Vectors: Long-term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity

Comparative integrome analyses have highlighted alpharetroviral vectors with a relatively neutral, and thus favorable, integration spectrum. However, previous studies used alpharetroviral vectors harboring viral coding sequences and intact long-terminal repeats (LTRs). We recently developed self-ina...

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Detalhes bibliográficos
Main Authors: Suerth, Julia D, Maetzig, Tobias, Brugman, Martijn H, Heinz, Niels, Appelt, Jens-Uwe, Kaufmann, Kerstin B, Schmidt, Manfred, Grez, Manuel, Modlich, Ute, Baum, Christopher, Schambach, Axel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345992/
https://ncbi.nlm.nih.gov/pubmed/22334016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.309
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